Ferrocenyl hydroxytamoxifen: A prototype for a new range of oestradiol receptor site-directed cytotoxics

被引:265
作者
Top, S
Tang, J
Vessieres, A
Carrez, D
Provot, C
Jaouen, G
机构
[1] ECOLE NATL SUPER CHIM,LAB CHIM ORGANOMET,URA,CNRS 403,F-75231 PARIS 05,FRANCE
[2] CTR UNIV ORSAY,INSERM 350,INST CURIE,BIOL SECT,F-91405 ORSAY,FRANCE
[3] SFRI,F-33127 ST JEAN DILLAC,FRANCE
关键词
D O I
10.1039/cc9960000955
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The synthesis of ferrocenyl hydroxytamoxifen 1, a prototype for a new range of oestradiol receptor site-directed cytotoxic compounds, and some preliminary biochemical tests are reported.
引用
收藏
页码:955 / 956
页数:2
相关论文
共 27 条
[1]   EFFECT OF TRIPHENYLACRYLONITRILE DERIVATIVES ON ESTRADIOL-RECEPTOR BINDING AND ON HUMAN-BREAST CANCER CELL-GROWTH [J].
BIGNON, E ;
PONS, M ;
DEPAULET, AC ;
DORE, JC ;
GILBERT, J ;
ABECASSIS, J ;
MIQUEL, JF ;
OJASOO, T ;
RAYNAUD, JP .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (09) :2092-2103
[2]   SULFATE DERIVATIVES OF 2-PHENYLINDOLS AS NOVEL STEROID SULFATASE INHIBITORS - AN INVITRO STUDY ON STRUCTURE-ACTIVITY-RELATIONSHIP [J].
BIRNBOCK, H ;
VONANGERER, E .
BIOCHEMICAL PHARMACOLOGY, 1990, 39 (11) :1709-1713
[3]   AROMATASE INHIBITORS - MECHANISMS OF STEROIDAL INHIBITORS [J].
BRUEGGEMEIER, RW .
BREAST CANCER RESEARCH AND TREATMENT, 1994, 30 (01) :31-42
[4]  
CORADINI D, 1994, ANTICANCER RES, V14, P1059
[5]   MULTIVARIATE-ANALYSIS BY THE MINIMUM SPANNING TREE METHOD OF THE STRUCTURAL DETERMINANTS OF DIPHENYLETHYLENES AND TRIPHENYLACRYLONITRILES IMPLICATED IN ESTROGEN-RECEPTOR BINDING, PROTEIN-KINASE-C ACTIVITY, AND MCF7 CELL-PROLIFERATION [J].
DORE, JC ;
GILBERT, J ;
BIGNON, E ;
DEPAULET, AC ;
OJASOO, T ;
PONS, M ;
RAYNAUD, JP ;
MIQUEL, JF .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (03) :573-583
[6]   SOME METHYLQUINOLINES PATTERNED AS OPEN MODELS OF ATEBRIN [J].
GILMAN, H ;
TOWLE, JL ;
SPATZ, SM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1946, 68 (10) :2017-2019
[7]   CURRENT PERSPECTIVES ON AROMATASE INHIBITORS IN BREAST-CANCER [J].
GOSS, PE ;
GWYN, KMEH .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (11) :2460-2470
[8]   STUDIES ON THE ANTITUMOR-ACTIVITY OF SOME IRON SANDWICH COMPOUNDS [J].
HOULTON, A ;
ROBERTS, RMG ;
SILVER, J .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1991, 418 (01) :107-112
[9]   A MODEL TO DESCRIBE HOW A POINT MUTATION OF THE ESTROGEN-RECEPTOR ALTERS THE STRUCTURE-FUNCTION RELATIONSHIP OF ANTIESTROGENS [J].
JIANG, SY ;
PARKER, CJ ;
JORDAN, VC .
BREAST CANCER RESEARCH AND TREATMENT, 1993, 26 (02) :139-147
[10]   ENDOCRINE PHARMACOLOGY OF ANTIESTROGENS AS ANTITUMOR AGENTS [J].
JORDAN, VC ;
MURPHY, CS .
ENDOCRINE REVIEWS, 1990, 11 (04) :578-610