Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?

被引：63

作者：

Bobbala, Sharan ^{[1
]}

Hook, Sarah ^{[1
]}

机构：

[1] Univ Otago, Sch Pharm, Dunedin 9054, New Zealand

来源：

PHARMACEUTICAL RESEARCH | 2016年 / 33卷 / 09期

关键词：

hydrogels; immunization; implants; nanoparticles; subunit vaccines; VIRUS-LIKE PARTICLES; CYTOTOXIC T-LYMPHOCYTE; IMMUNOSTIMULATORY BIODEGRADABLE IMPLANTS; INTRAMUSCULAR INFLUENZA VACCINES; LIQUID-CRYSTALLINE NANOPARTICLES; DENDRITIC CELL ACTIVATION; EMULSION-BASED ADJUVANTS; EXTRUDED LIPID IMPLANTS; IN-VIVO; ANTIBODY-RESPONSES;

D O I：

10.1007/s11095-016-1979-0

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Modern vaccine design has moved away from attenuated or inactivated whole-pathogen vaccines to more pure and defined subunit vaccines. However subunit antigens have poor bioavailability and stability and lack immunogenicity. To overcome these issues subunit vaccines have to be administered in a suitable delivery system in combination with immune stimulants. Many different delivery systems have been developed and investigated each having different modes of action, for example increasing delivery and/or sustaining delivery of antigen to immune cells. In addition a number of different routes of immunization are possible and these can play a crucial role in determining the fate of an immune response. In this review the different strategies for the delivery of prophylactic and therapeutic subunit vaccines along with the impact of these on the immune responses generated are discussed.

引用

收藏

页码：2078 / 2097

页数：20

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