Isoquinoline alkaloids from Thalictrum delavayi

被引：22

作者：

Li, M ^{[1
]}

Chen, X ^{[1
]}

Tang, QM ^{[1
]}

Zhang, JS ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Materia Med, Shanghai 200031, Peoples R China

来源：

PLANTA MEDICA | 2001年 / 67卷 / 02期

关键词：

D O I：

10.1055/s-2001-11518

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new protoberberine alkaloids, 2,3,9,10-dimethylenedioxy-8-oxoprotoberberine (1) and 2,3,9,10-dimethylenedioxy-1,8-dihydroxyprotoberberine (2), together with nine known isoquinoline-type alkaloids were isolated from the roots of Thalictrum delavayi. Their structures were elucidated by spectral methods. Among these compounds, pseudoprotopine showed competitive inhibition activity by DA receptor binding assay (D-1) in vitro. The competitive inhibitions were 87.5% (10(-4) M) and 15.6% (10(-6) M), respectively.

引用

页码：189 / 190

页数：2

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