Triplex technology in studies of DNA damage, DNA repair, and mutagenesis

被引：68

作者：

Mukherjee, Anirban ^{[1
]}

Vasquez, Karen M. ^{[1
]}

机构：

[1] Univ Texas Austin, Dell Pediat Res Inst, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78723 USA

来源：

BIOCHIMIE | 2011年 / 93卷 / 08期

关键词：

Triplex-forming oligonucleotides; DNA damage; DNA repair; Triplex technology; Recombination; Mutagenesis; DNA structure; INTERSTRAND CROSS-LINKS; HELIX-FORMING OLIGONUCLEOTIDE; NUCLEOTIDE EXCISION-REPAIR; PEPTIDE NUCLEIC-ACIDS; DOUBLE-STRAND BREAKS; ANTICANCER DRUG CISPLATIN; SELECTABLE MAMMALIAN GENE; REPLICATION PROTEIN-A; HOMOLOGOUS RECOMBINATION; BINDING PROTEIN;

D O I：

10.1016/j.biochi.2011.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triplex-forming oligonucleotides (TFOs) can bind to the major groove of homopurine-homopyrimidine stretches of double-stranded DNA in a sequence-specific manner through Hoogsteen hydrogen bonding to form DNA triplexes. TFOs by themselves or conjugated to reactive molecules can be used to direct sequence-specific DNA damage, which in turn results in the induction of several DNA metabolic activities. Triplex technology is highly utilized as a tool to study gene regulation, molecular mechanisms of DNA repair, recombination, and mutagenesis. In addition, TFO targeting of specific genes has been exploited in the development of therapeutic strategies to modulate DNA structure and function. in this review, we discuss advances made in studies of DNA damage, DNA repair, recombination, and mutagenesis by using triplex technology to target specific DNA sequences. (C) 2011 Elsevier Masson SAS. All rights reserved.

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页码：1197 / 1208

页数：12

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