One-year seizure prognosis in epilepsy patients treated with antidepressants

被引：17

作者：

Okazaki, Mitsutoshi ^{[1
]}

Adachi, Naoto ^{[1
,2
]}

Ito, Masumi ^{[1
,3
]}

Watanabe, Masako ^{[1
]}

Watanabe, Yutaka ^{[1
]}

Kato, Masaaki ^{[1
,4
]}

Onuma, Teiichi ^{[1
,4
]}

机构：

[1] Natl Ctr Hosp Neurol & Psychiat, Kodaira, Tokyo 1878551, Japan

[2] Adachi Mental Clin, Sapporo, Hokkaido, Japan

[3] Tenshi Hosp, Sapporo, Hokkaido, Japan

[4] Musashino Kokubunji Clin, Kokubunji, Tokyo, Japan

来源：

EPILEPSY & BEHAVIOR | 2011年 / 22卷 / 02期

关键词：

Epilepsy; Seizure frequency; Treatment; Antidepressant drugs; Depression; DEPRESSION; FLUOXETINE; IMIPRAMINE; SERTRALINE; FREQUENCY; CHILDREN; SUICIDE; DRUGS;

D O I：

10.1016/j.yebeh.2011.07.016

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

To investigate the clinical effects of antidepressants on seizure frequency of patients with epilepsy treated with antiepileptic drugs, we retrospectively evaluated the 1-year course of seizure frequency. One hundred twenty-one patients with epilepsy treated with antidepressants and 300 patients with epilepsy not treated with antidepressants (controls) were the subjects of this study. Seizure frequency over the 1-year period of administration of antidepressants was retrospectively evaluated and compared with that for controls. In the patients with epilepsy taking antidepressants, seizure frequencies at four observation points (1, 3, 6, and 12 months after starting antidepressants) were equivalent to those of the control group. There was no significant difference in seizure frequency between first- and second-generation antidepressants. Patients with epilepsy treated with antiepileptic drugs can take antidepressants without a significant risk of exacerbation of seizures. Most antidepressants can be used for psychiatric treatment of patients with epilepsy. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：331 / 335

页数：5

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