Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells

被引：79

作者：

Ballweber, Lamar ^{[1
]}

Robinson, Barry ^{[1
]}

Kreger, Allison ^{[2
]}

Fialkow, Michael ^{[2
]}

Lentz, Gretchen ^{[2
]}

McElrath, M. Juliana ^{[1
,3
,4
]}

Hladik, Florian ^{[1
,2
,3
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[2] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Med, Seattle, WA USA

[4] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 24期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN CERVICAL TISSUE; DENDRITIC CELLS; SEXUAL TRANSMISSION; SIV; LYMPHOCYTES; REPLICATION; MICROBICIDE; RECEPTOR; EVENTS;

D O I：

10.1128/JVI.05615-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4(+) T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle.

引用

页码：13443 / 13447

页数：5

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