Receptors and transduction in taste

被引:474
作者
Lindemann, B [1 ]
机构
[1] Univ Saarland, Dept Physiol, D-66421 Homburg, Germany
关键词
D O I
10.1038/35093032
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Taste is the sensory system devoted primarily to a quality check of food to be ingested. Although aided by smell and visual inspection, the final recognition and selection relies on chemoreceptive events in the mouth. Emotional states of acute pleasure or displeasure guide the selection and contribute much to our quality of life. Membrane proteins that serve as receptors for the transduction of taste have for a long time remained elusive. But screening the mass of genome sequence data that have recently become available has provided a new means to identify key receptors for bitter and sweet taste. Molecular biology has also identified receptors for salty, sour and umami taste.
引用
收藏
页码:219 / 225
页数:7
相关论文
共 101 条
[1]   A novel family of mammalian taste receptors [J].
Adler, E ;
Hoon, MA ;
Mueller, KL ;
Chandrashekar, J ;
Ryba, NJP ;
Zuker, CS .
CELL, 2000, 100 (06) :693-702
[2]   A BITTER SUBSTANCE INDUCES A RISE IN INTRACELLULAR CALCIUM IN A SUBPOPULATION OF RAT TASTE CELLS [J].
AKABAS, MH ;
DODD, J ;
ALAWQATI, Q .
SCIENCE, 1988, 242 (4881) :1047-1050
[3]  
[Anonymous], 1901, PHILOS STUDIEN
[4]   IP3 receptor type 3 and PLCβ2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells [J].
Asano-Miyoshi, M ;
Abe, K ;
Emori, Y .
CHEMICAL SENSES, 2001, 26 (03) :259-265
[5]   PATCH-CLAMP STUDY OF ISOLATED TASTE RECEPTOR-CELLS OF THE FROG [J].
AVENET, P ;
LINDEMANN, B .
JOURNAL OF MEMBRANE BIOLOGY, 1987, 97 (03) :223-240
[6]   NONINVASIVE RECORDING OF RECEPTOR CELL-ACTION POTENTIALS AND SUSTAINED CURRENTS FROM SINGLE TASTE-BUDS MAINTAINED IN THE TONGUE - THE RESPONSE TO MUCOSAL NACL AND AMILORIDE [J].
AVENET, P ;
LINDEMANN, B .
JOURNAL OF MEMBRANE BIOLOGY, 1991, 124 (01) :33-41
[7]   TRANSDUCTION IN TASTE RECEPTOR-CELLS REQUIRES CAMP-DEPENDENT PROTEIN-KINASE [J].
AVENET, P ;
HOFMANN, F ;
LINDEMANN, B .
NATURE, 1988, 331 (6154) :351-354
[8]   MEMBRANE CURRENTS IN TASTE CELLS OF THE RAT FUNGIFORM PAPILLA - EVIDENCE FOR 2 TYPES OF CA CURRENTS AND INHIBITION OF K-CURRENTS BY SACCHARIN [J].
BEHE, P ;
DESIMONE, JA ;
AVENET, P ;
LINDEMANN, B .
JOURNAL OF GENERAL PHYSIOLOGY, 1990, 96 (05) :1061-1084
[9]   Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat [J].
Bernhardt, SJ ;
Naim, M ;
Zehavi, U ;
Lindemann, B .
JOURNAL OF PHYSIOLOGY-LONDON, 1996, 490 (02) :325-336
[10]   Responses to glutamate in rat taste cells [J].
Bigiani, A ;
Delay, RJ ;
Chaudhari, N ;
Kinnamon, SC ;
Roper, SD .
JOURNAL OF NEUROPHYSIOLOGY, 1997, 77 (06) :3048-3059