Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats

被引：108

作者：

Zhao, Jing ^{[2
]}

Zhao, Yong ^{[1
]}

Zheng, Weiping ^{[2
]}

Lu, Yuyu ^{[1
]}

Feng, Gang ^{[1
]}

Yu, Shanshan ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Pathol, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Dept Pathophysiol, Chongqing 400016, Peoples R China

来源：

BRAIN RESEARCH | 2008年 / 1229卷

关键词：

curcumin; neuroprotection; middle cerebral artery occlusion; stroke;

D O I：

10.1016/j.brainres.2008.06.117

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Curcumin, a member of the curcuminoid family of compounds, is a yellow colored phenolic pigment obtained from the powdered rhizome of C. longa Linn. Recent studies have demonstrated that curcumin has protective effects against cerebral ischemia/reperfusion injury. However, little is known about its mechanism. Hence, in the present study the neuroprotective potential of curcumin was investigated in middle cerebral artery occlusion (MCAO) induced focal cerebral IR injury. Administration of curcumin 100 and 300 mg/kg i.p. 60 min after MCAO significantly diminished infarct volume, and improved neurological deficit in a dose-dependent manner. Nissl staining showed that the neuronal injury was significantly improved after being treated with curcumin. Curcumin significantly decreased the expression of caspase-3 protein. A higher number of TUNEL-positive cells were found in the vehicle group, but they were significantly decreased in the treated group. Taken together, these results suggest that the neuroprotective potentials of curcurnin against focal cerebral ischemic injury are, at least in part, ascribed to its anti-apoptotic effects. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：224 / 232

页数：9

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