Impact of preoperative serum carcinoembryonic antigen, CA 19-9 and alpha fetoprotein levels in gastric cancer patients

被引：41

作者：

Nakajima, K ^{[1
]}

Ochiai, T ^{[1
]}

Suzuki, T ^{[1
]}

Shimada, H ^{[1
]}

Hayashi, H ^{[1
]}

Yasumoto, A ^{[1
]}

Takeda, A ^{[1
]}

Hishikawa, E ^{[1
]}

Isono, K ^{[1
]}

机构：

[1] Chiba Univ, Sch Med, Dept Surg, Chuo Ku, Chiba 260, Japan

来源：

TUMOR BIOLOGY | 1998年 / 19卷 / 06期

关键词：

carcinoembryonic antigen; CA; 19-9; alpha fetoprotein; gastric cancer;

D O I：

10.1159/000030038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relationship between preoperative serum carcinoembryonic antigen (CEA), CA 19-9 and alpha-fetoprotein (AFP) levels and their clinicopathological features were evaluated in gastric cancer patients, The positive rates of CEA, CA 19-9 and AFP were 24.8, 27.6 and 12.7%, respectively. Gastric cancer with deeper tumor invasion was significantly more common among patients positive for these tumor markers, Patients with positive CEA or CA 19-9 values had a significantly high risk of lymph node metastases (p = 0.045 and p = 0.002, respectively), Synchronous liver metastases was more commonly found in patients with a positive CA 19-9 value. A significant difference (p < 0.001) in survival rate was found between patients with positive CA 19-9 values and those with negative values. CA 19-9 is useful for the prognosis of gastric cancer patients, whereas CEA, although unsuitable for prognosis, contributes to the prediction of cancer invasion.

引用

页码：464 / 469

页数：6

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