Fellowship of the rings: the replication of kinetoplast DNA

被引：181

作者：

Liu, BY ^{[1
]}

Liu, YN ^{[1
]}

Motyka, SA ^{[1
]}

Agbo, EEC ^{[1
]}

Englund, PT ^{[1
]}

机构：

[1] Johns Hopkins Med Sch, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 08期

关键词：

D O I：

10.1016/j.pt.2005.06.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most unusual features, a mitochondrial DNA known as kinetoplast DNA (kDNA). Unlike all other DNA in nature, kDNA comprises a giant network of interlocked DNA rings with a topology resembling that of medieval chain mail. The replication of the kDNA network is more complex than previously thought, and the discovery of new proteins involved in this process is currently the best approach for illuminating the replication mechanism.

引用

页码：363 / 369

页数：7

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