The mean platelet volume in patients with obesity

被引：230

作者：

Coban, E ^{[1
]}

Ozdogan, M

Yazicioglu, G

Akcit, F

机构：

[1] Akdeniz Univ, Fac Med, Dept Internal Med, Div Endocrinol & Metab, TR-07070 Antalya, Turkey

[2] Akdeniz Univ, Fac Med, Dept Biochem, TR-07070 Antalya, Turkey

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2005年 / 59卷 / 08期

关键词：

cardiovascular risk; obesity; mean platelet volume;

D O I：

10.1111/j.1742-1241.2005.00500.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. The present stud), was designed to evaluate MPV in patients with obesity compared with non-obese control subjects. We selected 100 non-obese subjects and 100 subjects With obesity [body mass index (BMI) >= 30 kg /m(2)] matched for age and gender. The MPV was significantly higher in obese group than in non-obese control group (10.3 +/- 1.2 vs. 9.0 +/- 0.8 fl, p < 0.01). MPV was positively correlated with BMI in obese group (p < 0.05). Increased MPV may be a possible cause for increased cardiovascular risk in patients with obesity.

引用

页码：981 / 982

页数：2

共 14 条

[1] Platelet size: Measurement, physiology and vascular disease [J].

Bath, PMW ;

Butterworth, RJ .

BLOOD COAGULATION & FIBRINOLYSIS, 1996, 7 (02) :157-161

[2] High sensitivity C-reactive protein: An emerging role in cardiovascular risk assessment [J].

Benzaquen, LR ;

Yu, H ;

Rifai, N .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2002, 39 (4-5) :459-497

[3] Supine rest reduces platelet activation and aggregation [J].

Broadley, AJM ;

Gapper, P ;

Schmitt, M ;

Frenneaux, MP .

PLATELETS, 2003, 14 (01) :3-7

[4] Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis [J].

Brown, AS ;

Hong, Y ;

deBelder, A ;

Beacon, H ;

Beeso, J ;

Sherwood, R ;

Edmonds, M ;

Martin, JF ;

Erusalimsky, JD .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (04) :802-807

[5] Mean platelet volume in type 2 diabetic patients [J].

Hekimsoy, Z ;

Payzin, B ;

Örnek, T ;

Kandogan, G .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2004, 18 (03) :173-176

[6]

KRISTENSEN SD, 1992, DAN MED BULL, V39, P110

[7] Platelet indexes in relation to target organ damage in high-risk hypertensive patients - A substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) [J].

Nadar, SK ;

Blann, AD ;

Kamath, S ;

Beevers, DG ;

Lip, GYH .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (02) :415-422

[8] Mean platelet volume as an indicator of platelet activation: methodological issues [J].

Park, Y ;

Schoene, N ;

Harris, W .

PLATELETS, 2002, 13 (5-6) :301-306

[9] Obesity and cardiovascular disease. [J].

Poirier P. ;

Eckel R.H. .

Current Atherosclerosis Reports, 2002, 4 (6) :448-453

[10]

SHARPE PC, 1993, Q J MED, V86, P739

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