Polymeric microspheres composed of pH/temperature-sensitive polymer complex

被引：73

作者：

Kim, EJ

Cho, SH

Yuk, SH

机构：

[1] Hannam Univ, Dept Polymer Sci & Engn, Taejon 306791, South Korea

[2] Korea Res Inst Chem Technol, Adv Mat Div, Taejon 305600, South Korea

来源：

BIOMATERIALS | 2001年 / 22卷 / 18期

关键词：

polymeric microsphere; pH/temperature-sensitive polymer mixture; on-off release of hydrocortisone;

D O I：

10.1016/S0142-9612(00)00439-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new pH/temperature-sensitive polymer system with transitions resulting both from polymer-water and polymer-polymer interactions has been demonstrated using the mixture of poly(N,N-dimethylamino) ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm). Based on the pH/temperature sensitivity of polymer mixture, the microsphere for pH/temperature-sensitive drug release have been designed and characterized. Hydrocortisone was used as a model drug. This gave the control of hydrocortisone release in an on-off manner without considerable lag time. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2495 / 2499

页数：5

共 14 条

[1] TEMPERATURE-RESPONSIVE INTERPENETRATING POLYMER NETWORKS CONSTRUCTED WITH POLY(ACRYLIC ACID) AND POLY(N,N-DIMETHYLACRYLAMIDE) [J].