Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su

被引：27

作者：

Kamano, Y

Morita, H

Takano, R

Kotake, A

Nogawa, T

Hashima, H

Takeya, K

Itokawa, H

Pettit, GR

机构：

[1] Kanagawa Univ, Fac Sci, Hiratsuka, Kanagawa 2591293, Japan

[2] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

[3] Arizona State Univ, Canc Res Inst, Tempe, AZ 85287 USA

[4] Arizona State Univ, Dept Chem, Tempe, AZ 85287 USA

来源：

HETEROCYCLES | 1999年 / 50卷 / 01期

关键词：

D O I：

10.3987/COM-98-S(H)55

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Two new bioactive indole alkaloids, 5-hydroxytryptamine (serotonin) N-4-oxobutanoic acid and 5-hydroxytryptamine N-acetyl-N-pyrrolecarboxamide, named as bufobutanoic acid (2) and bufopyramide (3), respectively, were isolated from the Chinese traditional drug Ch'an Su in addition to known bufotenine (1). The structures were elucidated on the basis of spectroscopic data. Bufobutanoic acid (2) and bufopyramide (3) exhibited cytotoxicity against murine P388 lymphocytic leukemia cells with IC50 Values of 22 mu g/mL and 7.6 mu g/mL, respectively.

引用

页码：499 / 503

页数：5