Inhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates

被引：10

作者：

Duan, CY

Poticha, D

Stoeckli, TC

Petropoulos, CJ

Whitcomb, JM

McHenry, CS

Kuritzkes, DR

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Genet, Denver, CO 80262 USA

[3] ViroLogic, S San Francisco, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2001年 / 184卷 / 10期

关键词：

D O I：

10.1086/323995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cross-resistance between zidovudine, stavudine, and lamivudine was studied, using purified recombinant reverse transcriptase from a zidovudine-susceptible and -resistant pair of clinical isolates of human immunodeficiency virus type 1. The zidovudine-resistant isolate exhibited low-level cross-resistance to both stavudine and lamivudine in drug susceptibility assays. Enzyme from the resistant isolate demonstrated reduced inhibition by zidovudine triphosphate and stavudine triphosphate and, to a lesser extent, lamivudine triphosphate. These findings provide additional evidence at the viral and enzyme level for cross-resistance between zidovudine and stavudine, and they suggest a possible effect of zidovudine resistance on susceptibility to lamivudine.

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收藏

页码：1336 / 1340

页数：5

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