Opportunities for novel therapeutic agents acting at chemokine receptors

Chemokines are proinflammatory mediators that primarily control leukocyte migration into selected tissues and upregulation of adhesion:receptors. They also have a role in pathological conditions that require neovascularization and are implicated in the suppression of viral replication. By interaction with their respective G-protein-coupled receptor, chemokines have a profound influence cover the selective recruitment of specific cell types in acute inflammatory disease and, hence, inhibition of their action should be Of therapeutic benefit. Only now are small molecule inhibitors becoming available tb validate this speculation. In this review without seeking to be comprehensive, the authors provide an introduction to chemokines, their receptors and their role in certain disease processes, Also, recent disclosures claiming novel nonpeptide ligands for chemokine receptors are summarized.