Long-term effect of arsenic exposure: Results from an occupational cohort study

被引：20

作者：

Gianicolo, Emilio Antonio L. ^{[1
,2
]}

Mangia, Cristina ^{[3
]}

Cervino, Marco ^{[4
]}

Bruni, Antonella ^{[5
]}

Portaluri, Maurizio ^{[6
]}

Comba, Pietro ^{[7
]}

Pirastu, Roberta ^{[8
]}

Biggeri, Annibale ^{[9
,10
]}

Vigotti, Mariangela ^{[1
]}

Blettner, Maria ^{[2
]}

机构：

[1] Italian Natl Res Council, Inst Clin Physiol, Lecce, Italy

[2] Johannes Gutenberg Univ Mainz, Inst Med Biostat Epidemiol & Informat, Obere Zahlbacher Str 69, D-55131 Mainz, Germany

[3] Italian Natl Res Council, Inst Atmospher Sci & Climate, Lecce, Italy

[4] Italian Natl Res Council, Inst Atmospher Sci & Climate, Bologna, Italy

[5] Azienda Sanit Locale, Epidemiol & Stat Unit, Taranto, Italy

[6] Gen Hosp, Dept Radiotherapy, Brindisi, Italy

[7] Ist Super Sanita, Dept Environm & Hlth, Rome, Italy

[8] Univ Roma, Fdn Sapienza, Rome, Italy

[9] Univ Florence, Dept Stat Comp Sci Applicat, Florence, Italy

[10] Epidemiol & Prevenz Social Enterprise, Turin, Italy

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2019年 / 62卷 / 02期

关键词：

arsenic; epidemiology of disasters; industrial accident; lung cancer; petrochemical plant; HEALTHY WORKER; RESPIRATORY CANCER; MORTALITY; CONTAMINATION; MANFREDONIA; ASSOCIATION; DISEASE; LUNG;

D O I：

10.1002/ajim.22939

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Background In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities. Methods The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of interest was mortality for specific causes. Standardized mortality ratios (SMR) and 95% confidence intervals (95%CI) were computed. Results For all workers and all causes of death combined, the SMR was less than 1.0. Mortality ratios were increased for malignant neoplasms of the pleura, bone and melanoma of the skin. Contract workers, the group mostly exposed to arsenic, showed statistically significant SMRs for several malignancies, in particular for lung cancer (SMR = 1.26; 95%CI: 1.05-1.54). Conclusions Overall, the results reported here on mortality among persons occupationally exposed to arsenic are consistent with the literature and biologically plausible.

引用

页码：145 / 155

页数：11

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