Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation

被引：126

作者：

Kostova, Zlatka ^{[1
]}

Tsai, Yien Che ^{[1
]}

Weissman, Allan M. ^{[1
]}

机构：

[1] Natl Canc Inst, Canc Res Ctr, Lab Prot Dynam & Signalling, NIH, Frederick, MD 21702 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 06期

关键词：

endoplasmic reticulum-associated degradation; ubiquitin protein ligase (E3); proteasome; Saccharomyces cerevisiae;

D O I：

10.1016/j.semcdb.2007.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action. Published by Elsevier Ltd.

引用

页码：770 / 779

页数：10

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