Hormone replacement therapy: what is the evidence today?

被引：1

作者：

Uebelhart, B ^{[1
]}

Frey, D

Uebelhart, D

机构：

[1] Univ Hosp, Dept Geriatr, Div Bone Dis, CH-1211 Geneva 14, Switzerland

[2] Univ Zurich Hosp, Dept Rheumatol, CH-8091 Zurich, Switzerland

[3] Univ Zurich Hosp, Inst Med Phys, CH-8091 Zurich, Switzerland

[4] Univ Zurich Hosp, Osteoporosis Ctr, CH-8091 Zurich, Switzerland

来源：

ZEITSCHRIFT FUR RHEUMATOLOGIE | 2003年 / 62卷 / 06期

关键词：

hormone replacement therapy; fracture prevention; cancer incidence; cariovascular diseases; cognitive functions; quality of life; HERS; WHI;

D O I：

10.1007/s00393-003-0559-y

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Based on the most recent studies, it clearly appears that long-term hormone replacement therapy (HRT) prevents fractures but does not improve established coronary artery disease. in addition, HRT leads to a small increase in breast cancer incidence and to a decrease in colorectal cancer incidence. HRT increases the incidence of venous thrombosis, pulmonary embolisms and strokes. As a consequence, HRT can no longer be recommended for primary or secondary prevention of cardiovascular diseases. In addition, it was also demonstrated that HRT was not able to improve cognitive functions and prevent dementia. Therefore regarding daily clinical practice, HRT certainly remains useful to control the symptoms of oestrogen deficiency in recently menopausal patients, but it should definitively no longer be recommended for long-term treatment.

引用

页码：508 / 511

页数：6

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