Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development

被引：36

作者：

Gómez-Skarmeta, JL

de la Calle-Mustienes, E

Modolell, J

Mayor, R

机构：

[1] Univ Chile, Fac Ciencias, Lab Biol Desarrollo, Santiago, Chile

[2] CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[3] Univ Autonoma Madrid, E-28049 Madrid, Spain

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 80卷 / 01期

关键词：

Xbf2; mesoderm; neural induction; neural crest; Xenopus;

D O I：

10.1016/S0925-4773(98)00190-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes. Indeed, XbfZ overexpression caused partial axis duplication. Interference with BMP-4 signaling also occurs in isolated animal caps, since Xbf2 induces neural tissue. Within the neurula forebrain, Xbf2 and the related Xbf1 gene are expressed in the contiguous diencephalic and telencephalic territories, respectively, and each gene represses the other. Finally, Xbf2 seems to participate in the control of neural crest migration. Our data suggest that XBF2 interferes with BMP-4 signaling, both in mesoderm and ectoderm. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：15 / 27

页数：13

共 61 条

[1] ALTABA ARI, 1992, DEVELOPMENT, V116, P81
[2] BLITZ IL, 1995, DEVELOPMENT, V121, P993
[3] MOLECULAR NATURE OF SPEMANNS ORGANIZER - THE ROLE OF THE XENOPUS HOMEOBOX GENE GOOSECOID
CHO, KWY
BLUMBERG, B
STEINBEISSER, H
DEROBERTIS, EM
[J]. CELL, 1991, 67 (06) : 1111 - 1120
[4] CHRISTIAN JL, 1991, DEVELOPMENT, V111, P1045
[5] CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE-H5
CLARK, KL
HALAY, ED
LAI, ES
BURLEY, SK
[J]. NATURE, 1993, 364 (6436) : 412 - 420
[6] IDENTIFICATION OF 9 TISSUE-SPECIFIC TRANSCRIPTION FACTORS OF THE HEPATOCYTE NUCLEAR FACTOR-III FORKHEAD DNA-BINDING-DOMAIN FAMILY
CLEVIDENCE, DE
OVERDIER, DG
TAO, WF
QIAN, XB
PANI, L
LAI, EE
COSTA, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) : 3948 - 3952
[7] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
DEVEREUX, J
HAEBERLI, P
SMITHIES, O
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (01) : 387 - 395
[8] A NOVEL, ACTIVIN-INDUCIBLE, BLASTOPORE LIP-SPECIFIC GENE OF XENOPUS-LAEVIS CONTAINS A FORK HEAD DNA-BINDING DOMAIN
DIRKSEN, ML
JAMRICH, M
[J]. GENES & DEVELOPMENT, 1992, 6 (04) : 599 - 608
[9] Dosch R, 1997, DEVELOPMENT, V124, P2325
[10] Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites
Freyaldenhoven, BS
Freyaldenhoven, MP
Iacovoni, JS
Vogt, PK
[J]. ONCOGENE, 1997, 15 (04) : 483 - 488

← 1 2 3 4 5 6 7 →