Mucosal and systemic antibody responses in humans infected with simian foamy virus

被引：11

作者：

Cummins, JE

Boneva, RS

Switzer, WM

Christensen, LL

Sandstrom, P

Heneine, W

Chapman, LE

Dezzutti, CS

机构：

[1] Ctr Dis Control & Prevent, HIV & Retrovirol Branch, Div AIDS STD, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, TB Lab Res, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA

[3] Hlth Canada, Ctr Infect Dis Prevent & Control, Bur HIV AIDS STD & TB, Ottawa, ON K1A 0L2, Canada

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 20期

关键词：

D O I：

10.1128/JVI.79.20.13186-13189.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.

引用

收藏

页码：13186 / 13189

页数：4

相关论文

共 30 条

[1] IgA immunity in HIV type 1-infected chimpanzees .1. Systemic immunity [J].

Black, KP ;

Fultz, PN ;

Girard, M ;

Jackson, S .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1997, 13 (15) :1263-1272

[2] Simian foamy virus infections in a baboon breeding colony [J].

Blewett, EL ;

Black, DH ;

Lerche, NW ;

White, G ;

Eberle, R .

VIROLOGY, 2000, 278 (01) :183-193

[3] Simian foamy virus infection in a blood donor [J].

Boneva, RS ;

Grindon, AJ ;

Orton, SL ;

Switzer, WM ;

Shanmugam, V ;

Hussain, AI ;

Bhullar, VB ;

Chamberland, ME ;

Heneine, W ;

Folks, TM ;

Chapman, LE .

TRANSFUSION, 2002, 42 (07) :886-891

[4] Cross-species retroviral transmission from macaques to human beings [J].

Brooks, JI ;

Rud, EW ;

Pilon, RG ;

Smith, JM ;

Switzer, WM ;

Sandstrom, PA .

LANCET, 2002, 360 (9330) :387-388

[5] CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-γ in response to p24 antigen in HIV-infected individuals:: Potential contribution of anergy to HIV-specific unresponsiveness [J].

Dybul, M ;

Mercier, G ;

Belson, M ;

Hallahan, CW ;

Liu, SY ;

Perry, C ;

Herpin, B ;

Ehler, L ;

Davey, RT ;

Metcalf, JA ;

Mican, JM ;

Seder, RA ;

Fauci, AS .

JOURNAL OF IMMUNOLOGY, 2000, 165 (03) :1685-1691

[6] Sites of simian foamy virus persistence in naturally infected African green monkeys:: Latent provirus is ubiquitous, whereas viral replication is restricted to the oral mucosa [J].

Falcone, V ;

Leupold, J ;

Clotten, J ;

Urbanyi, E ;

Herchenröder, O ;

Spatz, W ;

Volk, B ;

Böhm, N ;

Toniolo, A ;

Neumann-Haefelin, D ;

Schweizer, M .

VIROLOGY, 1999, 257 (01) :7-14

[7] INDUCTION OF ANERGY OR ACTIVE SUPPRESSION FOLLOWING ORAL TOLERANCE IS DETERMINED BY ANTIGEN DOSAGE [J].

FRIEDMAN, A ;

WEINER, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6688-6692

[8] REACTIVITY OF PRIMATE SERA TO FOAMY VIRUS GAG AND BET PROTEINS [J].

HAHN, H ;

BAUNACH, G ;

BRAUTIGAM, S ;

MERGIA, A ;

NEUMANNHAEFELIN, D ;

DANIEL, MD ;

MCCLURE, MO ;

RETHWILM, A .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :2635-2644

[9]

Heneine W, 2003, CURR TOP MICROBIOL, V277, P181

[10] Identification of a human population infected with simian foamy viruses [J].

Heneine, W ;

Switzer, WM ;

Sandstrom, P ;

Brown, J ;

Vedapuri, S ;

Schable, CA ;

Khan, AS ;

Lerche, NW ;

Schweizer, M ;

Neumann-Haefelin, D ;

Chapman, LE ;

Folks, TM .

NATURE MEDICINE, 1998, 4 (04) :403-407