Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress

被引：137

作者：

Liu, Xiu-Fen ^{[1
]}

Hao, Ji-Long ^{[1
]}

Xie, Tian ^{[2
]}

Malik, Tayyab Hamid ^{[3
]}

Lu, Cheng-Bo ^{[4
]}

Liu, Cong ^{[1
]}

Shu, Chang ^{[5
]}

Lu, Cheng-Wei ^{[1
]}

Zhou, Dan-Dan ^{[6
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Ophthalmol, Changchun, Jilin, Peoples R China

[2] Peoples Hosp Jilin Prov, Dept Neurosurg, Changchun, Jilin, Peoples R China

[3] Jilin Univ, Hosp 1, Dept Gastroenterol, Changchun, Jilin, Peoples R China

[4] Jiamusi Univ, Hosp 1, Dept Cardiol, Jiamusi, Heilongjiang, Peoples R China

[5] Jilin Univ, Hosp 1, Dept Obstet & Gynecol, Changchun, Jilin, Peoples R China

[6] Jilin Univ, Hosp 1, Dept Radiol, Changchun, Jilin, Peoples R China

来源：

AGING CELL | 2017年 / 16卷 / 05期

关键词：

antioxidant response element; cataracts; Keap1; lenses; Nrf2; oxidative stress; ENDOPLASMIC-RETICULUM STRESS; LENS EPITHELIAL-CELLS; GENETICALLY HETEROGENEOUS MICE; EXTENDS LIFE-SPAN; GENE-EXPRESSION; RESPONSE ELEMENT; C-ELEGANS; ANTIOXIDANT PROTECTION; DNA DEMETHYLATION; SENESCENT CELLS;

D O I：

10.1111/acel.12645

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cataract is one of the most important causes of blindness worldwide, with age-related cataract being the most common one. Agents preventing cataract formation are urgently required. Substantial evidences point out aggravated oxidative stress as a vital factor for cataract formation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) system is considered as one of the main cellular defense mechanisms against oxidative stresses. This review discusses the role of Nrf2 pathway in the prevention of cataracts and highlights that Nrf2 suppressors may augment oxidative stress of the lens, and Nrf2 inducers may decrease the oxidative stress and prevent the cataract formation. Thus, Nrf2 may serve as a promising therapeutic target for cataract treatment.

引用

页码：934 / 942

页数：9

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