Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level

被引：1

作者：

Zhao, Feng ^{[1
,2
]}

He, En-Qi ^{[1
]}

Wang, Lu ^{[1
]}

Liu, Ke ^{[1
,2
]}

机构：

[1] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

[2] Yantai Target Drug Res Co Ltd, Yantai 264006, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 05期

关键词：

andrographolide; anti-tumor activity; apoptosis; caspase; 3; bax; bcl-2;

D O I：

10.1080/10286020801948334

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most sensitive cell line among the cell lines screened) via the activation of caspase 3, up-regulation of bax, and down-regulation of bcl-2. Furthermore, its inhibitory activity on the level of vascular endothelial growth factor was also verified by ELISA.

引用

页码：473 / 479

页数：7

共 13 条

[1] The BCL2 family: Regulators of the cellular life-or-death switch [J].

Cory, S ;

Adams, JM .

NATURE REVIEWS CANCER, 2002, 2 (09) :647-656

[2] Dissecting the pathways to death [J].

Daniel, PT .

LEUKEMIA, 2000, 14 (12) :2035-2044

[3] Mitochondria as the central control point of apoptosis [J].

Desagher, S ;

Martinou, JC .

TRENDS IN CELL BIOLOGY, 2000, 10 (09) :369-377

[4] Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane [J].

Eskes, R ;

Desagher, S ;

Antonsson, B ;

Martinou, JC .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (03) :929-935

[5]

Gasparini G, 2000, Oncologist, V5 Suppl 1, P37

[6]

HANDA SS, 1990, INDIAN J MED RES-B, V92, P276

[7] The biochemistry of apoptosis [J].

Hengartner, MO .

NATURE, 2000, 407 (6805) :770-776

[8] Semisynthesis and cytotoxic activities of andrographolide analogues [J].

Jada, Srinivasa Rao ;

Hamzah, Ahmad Sazali ;

Lajis, Nordin Haji ;

Saad, Mohammad Said ;

Stevens, Malcolm F. G. ;

Stanslas, Johnson .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2006, 21 (02) :145-155

[9]

LI J, 2007, EUR J PHARMACOL, V1, P31

[10] Death by a thousand cuts: an ever increasing list of caspase substrates [J].

Stroh, C ;

Schulze-Osthoff', K .

CELL DEATH AND DIFFERENTIATION, 1998, 5 (12) :997-1000

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