In vivo effects of estrogen on human brain

被引：13

作者：

Cutter, WJ

Craig, M

Norbury, R

Robertson, DM

Whitehead, M

Murphy, DG

机构：

[1] Inst Psychiat, Dept Psychol Med, Sect Brain Maturat, London SE5 8AF, England

[2] Kings Coll London, Sch Med, Menopause Clin, London SE5 9RS, England

来源：

STEROIDS AND THE NERVOUS SYSTEM | 2003年 / 1007卷

关键词：

estrogen; cognition; depression; aging; Alzheimer's disease; serotonin; acetylcholine; dopamine; noradrenaline;

D O I：

10.1196/annals.1286.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Age-related brain disorders such as Alzheimer's disease (AD) are becoming increasingly prevalent. Estrogen replacement therapy (ERT) has shown potential both as a preventive measure and treatment for such disorders. Good evidence from basic science demonstrates that estrogen has multiple protective effects on neurons and neurotransmitter systems, and the effects of ERT can be demonstrated on the human brain using techniques such as functional neuroimaging. However, the evidence for estrogen's having a clinical role in the treatment and prevention of neuropsychiatric disorders is not well established. In this article we review research into the effects of estrogen on the human brain and we consider the role for ERT as a therapeutic tool.

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页码：79 / 88

页数：10

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