Epitope mapping of a monoclonal antibody specific to feline panleukopenia virus and mink enteritis virus

被引：18

作者：

Horiuchi, M

Mochizuki, M

Ishiguro, N

Nagasawa, H

Shinagawa, M

机构：

[1] OBIHIRO UNIV AGR & VET MED,RES CTR PROTOZOAN MOL IMMUNOL,OBIHIRO,HOKKAIDO 080,JAPAN

[2] KYORITSU SHOJI CO,LAB CLIN MICROBIOL,CHIYODA KU,TOKYO 102,JAPAN

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1997年 / 59卷 / 02期

关键词：

canine parvovirus; feline panleukopenia virus; monoclonal antibody;

D O I：

10.1292/jvms.59.133

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

To obtain monoclonal antibodies (MAbs) specific to feline panleukopenia virus (FPLV) and mink enteritis virus (MEV), 15 hybridomas secreting MAbs against MEV-Abashiri were established and the properties of the MAbs were analyzed. The cross-reactivity of MAbs revealed that one MAb, P2-215 was specific for FPLV and MEV, whereas the remaining fourteen MAbs reacted with canine parvovirus (CPV), FPLV, and MEV. Epitope analyses using various CPV/MEV chimeric viruses revealed that the MAb P2-215 recognized the epitope comprised of amino acid 93-Lys in VP2, which is known to be FPLV and MEV-specific.

引用

页码：133 / 136

页数：4

共 18 条

[1] STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES
AGBANDJE, M
MCKENNA, R
ROSSMANN, MG
STRASSHEIM, ML
PARRISH, CR
[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1993, 16 (02): : 155 - 171
[2] MULTIPLE AMINO-ACIDS IN THE CAPSID STRUCTURE OF CANINE PARVOVIRUS COORDINATELY DETERMINE THE CANINE HOST RANGE AND SPECIFIC ANTIGENIC AND HEMAGGLUTINATION PROPERTIES
CHANG, SF
SGRO, JY
PARRISH, CR
[J]. JOURNAL OF VIROLOGY, 1992, 66 (12) : 6858 - 6867
[3] STRUCTURE, SEQUENCE, AND FUNCTION CORRELATIONS AMONG PARVOVIRUSES
CHAPMAN, MS
ROSSMANN, MG
[J]. VIROLOGY, 1993, 194 (02) : 491 - 508
[4] MAPPING OF DETERMINANTS OF THE HOST-RANGE FOR CANINE CELLS IN THE GENOME OF CANINE PARVOVIRUS USING CANINE PARVOVIRUS MINK ENTERITIS VIRUS CHIMERIC VIRUSES
HORIUCHI, M
GOTO, H
ISHIGURO, N
SHINAGAWA, M
[J]. JOURNAL OF GENERAL VIROLOGY, 1994, 75 : 1319 - 1328
[5] CHARACTERIZATION OF THE STAGE(S) IN THE VIRUS-REPLICATION CYCLE AT WHICH THE HOST-CELL SPECIFICITY OF THE FELINE PARVOVIRUS SUBGROUP IS REGULATED IN CANINE CELLS
HORIUCHI, M
ISHIGURO, N
GOTO, H
SHINAGAWA, M
[J]. VIROLOGY, 1992, 189 (02) : 600 - 608
[6] HORIUCHI M, IN PRESS VET MICROBI
[7] ANTIGENIC AND GENOMIC COMPARISONS OF SOME FELINE PARVOVIRUS SUBSPECIES STRAINS
MOCHIZUKI, M
KAWABATA, H
WANG, JS
[J]. JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH, 1991, 38 (02): : 99 - 105
[8] Isolation of canine parvovirus from a cat manifesting clinical signs of feline panleukopenia
Mochizuki, M
Horiuchi, M
Hiragi, H
SanGabriel, MC
Yasuda, N
Uno, T
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (09) : 2101 - 2105
[9] Parrish C R, 1990, Adv Virus Res, V38, P403
[10] RAPID ANTIGENIC-TYPE REPLACEMENT AND DNA-SEQUENCE EVOLUTION OF CANINE PARVOVIRUS
PARRISH, CR
AQUADRO, CF
STRASSHEIM, ML
EVERMANN, JF
SGRO, JY
MOHAMMED, HO
[J]. JOURNAL OF VIROLOGY, 1991, 65 (12) : 6544 - 6552

← 1 2 →