Ripply2 is essential for precise somite formation during mouse early development

被引：36

作者：

Cha, Techuan

Kondow, Akiko

Hosoya, Akihiro

Hitachi, Keisuke

Yukita, Akira

Okabayashi, Koji

Nakamura, Hiroaki

Ozawa, Hidehiro

Kiyonari, Hiroshi

Michiue, Tatsuo

Ito, Yuzuru

Asashima, Makoto

机构：

[1] Univ Tokyo, Dept Life Sci Biol, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

[2] Japan Sci & Technol Agcy, ICORP, Organ Regenerat Project, Meguro Ku, Tokyo 1538902, Japan

[3] Matsumoto Dent Univ, Dept Oral Hist, Nagano 3990781, Japan

[4] Matsumoto Dent Univ, Grad Sch Oral Med, Inst Oral Sci, Nagano 3990781, Japan

[5] RIKEN Kobe, Lab Anim Resources & Genet Engn, Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

[6] Natl Inst Adv Ind Sci & Technol, Organ Dev Res Lab, Tsukuba, Ibaraki 3058562, Japan

来源：

FEBS LETTERS | 2007年 / 581卷 / 14期

关键词：

Ripply; somitogenesis; Notch2; Uncx4; 1; skeleton; mouse;

D O I：

10.1016/j.febslet.2007.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebratish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2691 / 2696

页数：6

共 19 条

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