NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix

被引：63

作者：

Dent, Myrna A. R. ^{[2
]}

Segura-Anaya, Edith ^{[1
,2
]}

Alva-Medina, Janeth ^{[1
,2
]}

Aranda-Anzaldo, Armando ^{[1
]}

机构：

[1] Univ Autonoma Estado Mexico, Fac Med, Mol Biol Lab, Toluca 50000, Edo Mex, Mexico

[2] Univ Autonoma Estado Mexico, Fac Med, Lab Neurociencias, Toluca 50000, Edo Mex, Mexico

来源：

FEBS LETTERS | 2010年 / 584卷 / 13期

关键词：

Nucleoid; Speckle; Splicing; SPLICING FACTOR-RICH; TOPOISOMERASE-II; LIVING CELLS; DNA; PROTEINS; ASSOCIATION; SPECKLES; VISUALIZATION; TRANSCRIPTION; LOCALIZATION;

D O I：

10.1016/j.febslet.2010.04.073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

NeuN is an antigen detected in the nucleus of neurons in a wide range of vertebrates and so it is widely used as a tool for detecting neuronal cells. NeuN has been recently identified as Fox-3, a new member of the Fox-1 gene family of splicing factors. The predominant localization of NeuN/Fox-3 to neuronal nuclei and its role in splicing pose the question of the nuclear compartmentalization of such a protein. Here we provide evidence that NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix and a reliable marker of nuclear speckles in neurons.

引用

页码：2767 / 2771

页数：5

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