Intrasteric regulation of MDM2

被引：25

作者：

Shimizu, H ^{[1
]}

Hupp, TR ^{[1
]}

机构：

[1] Univ Dundee, Dept Mol & Cellular Pathol, Canc Res UK Labs, Dundee DD1 9SY, Scotland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(03)00140-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oncoprotein murine double minute 2 (MDM2) binds to the tumour suppressor protein p53 and negatively regulates growth suppression by catalyzing the ubiquitination and degradation of p53. Antagonizing MDM2 is an ataxia telangiectasia mutated (ATM) kinase- and checkpoint kinase-2 (CHK2) -dependent DNA-damage-inducible pathway that phosphorylates p53, releases p53 from MDM2 control and stabilizes the p300-p53 transcription complex. A recent report has identified a pseudo-substrate domain in MDM2 that can act as a lid to cover the hydrophobic MDM2-pocket and suggests a novel mechanism for control of the stability of the MDM2-p53 protein complex in vivo.

引用

页码：346 / 349

页数：4

共 29 条

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