Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression

被引：230

作者：

Chen, Wei ^{[1
,2
]}

Quan, Yingyao ^{[3
]}

Fan, Shaoyi ^{[4
]}

Wang, Hua ^{[2
,5
]}

Liang, Jinyu ^{[2
,6
]}

Huang, Li ^{[1
,2
]}

Chen, Liuhua ^{[1
,2
]}

Liu, Qi ^{[1
,2
]}

He, Peiheng ^{[2
,5
]}

Ye, Yibiao ^{[7
,8
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pancreatobiliary Surg, Zhongshan Second Rd 58, Guangzhou 510080, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, 58 Zhongshan Second Rd, Guangzhou 510080, Peoples R China

[3] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr, Zhuhai Hosp Affiliated, Zhuhai 519000, Peoples R China

[4] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510405, Peoples R China

[5] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Orthoped, 58 Zhongshan Second Rd, Guangzhou 510080, Peoples R China

[6] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Ultrason, 58 Zhongshan Second Rd, Guangzhou 510080, Peoples R China

[7] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Hepatobilliary Surg, 107 West Yanjiang Rd, Guangzhou 510120, Peoples R China

[8] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Key Lab Malignant Tumor Gene Regulat & Target The, Guangdong Higher Educ Inst, 1-7 West Yanjiang Rd, Guangzhou 510120, Peoples R China

来源：

CANCER LETTERS | 2020年 / 475卷

关键词：

Liver cancer; circRNA; Extracellular vesicles; Biomarker; miRNA; CELL-PROLIFERATION; CANCER; BAK1; APOPTOSIS; ROLES; HCC;

D O I：

10.1016/j.canlet.2020.01.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Extracellular communication in the tumor microenvironment is critical. Results of qRT-PCR show that circ0051443 is significantly lower in the plasma exosomes and tissues from patients with hepatocellular carcinoma (HCC) than healthy controls. Compared with the producer cells, circ-0051443 is mainly packaged into exosomes. A receiver operating characteristic curve (ROC) shows that the patients with HCC can be distinguished from the controls by exosomal circ-0051443. The role of exosomal circ-0051443 in HCC was determined by animal and cell analyses. Circ-0051443 is transmitted from normal cells to HCC cells via exosomes and suppresses the malignant biological behaviors by promoting cell apoptosis and arresting the cell cycle. Exosomal circ-0051443 decreases the weight and volume of the xenograft tumors in nude mice via BAK1 upregulation in these tumors. BAK1 expression is mediated by exosomal circ-0051443 through competitive bound to miR-331-3p. Therefore, exosomal circ-0051443 can serve as a predictor and potential therapeutic target for HCC.

引用

页码：119 / 128

页数：10

共 36 条

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