Critical roles for transcription factor GATA-3 in thymocyte development

被引:282
作者
Pai, SY
Truitt, ML
Ting, CN
Leiden, JM
Glimcher, LH
Ho, IC [1 ]
机构
[1] Dana Farber Canc Inst, Dept Pediat Hematol & Oncol, Boston, MA 02115 USA
[2] Childrens Hosp, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Ctr Prevent Cardiovasc Dis, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Div Infect Dis & Immunol, Boston, MA 02115 USA
[6] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
关键词
D O I
10.1016/S1074-7613(03)00328-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 in the thymus. To address this, we generated mice deficient in GATA-3 at early and late stages of thymic differentiation. Our studies revealed that GATA-3 is involved in beta selection and is indispensable for single-positive CD4 thymocyte development. Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells.
引用
收藏
页码:863 / 875
页数:13
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