Critical roles for transcription factor GATA-3 in thymocyte development

被引：282

作者：

Pai, SY

Truitt, ML

Ting, CN

Leiden, JM

Glimcher, LH

Ho, IC ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Hematol & Oncol, Boston, MA 02115 USA

[2] Childrens Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Ctr Prevent Cardiovasc Dis, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Div Infect Dis & Immunol, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA

来源：

IMMUNITY | 2003年 / 19卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(03)00328-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 in the thymus. To address this, we generated mice deficient in GATA-3 at early and late stages of thymic differentiation. Our studies revealed that GATA-3 is involved in beta selection and is indispensable for single-positive CD4 thymocyte development. Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells.

引用

页码：863 / 875

页数：13

共 44 条

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