Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties

被引:26
作者
Fragopoulou, E
Antonopoulou, S [1 ]
Nomikos, T
Demopoulos, CA
机构
[1] Natl & Kapodistrian Univ Athens, Fac Chem, Athens 15771, Greece
[2] Harokopio Univ, Dept Sci Nutr Dietet, Athens 17671, Greece
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2003年 / 1632卷 / 1-2期
关键词
wine; platelet activating factor; phenolic; antiatherogenic; electrospray mass spectrometry (ESMS);
D O I
10.1016/S1388-1981(03)00066-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The oxidative modification of low-density lipoproteins (LDL) is supposed to play a critical role in atherogenesis. During this oxidation a potent inflammatory phospholipid mediator named platelet activating factor (PAF) is produced, and it is believed to be the key for the initiation of the inflammation and therefore for the process of atherogenesis. From many studies, it is established that wine has beneficial effects on health,, including protection against cardiovascular diseases. According to our point of view, the cardioprotective effect of wine may be attributed partly to the existence of PAF antagonists in red or white wine and partly to the existence of antioxidants that reduce the oxidation of LDL and therefore the production of PAF. In this study, wine compounds that antagonize PAF were isolated and purified via chromatographic procedures, and determined structurally using chemical, enzymatic and spectroscopic methods. (C) 2003 Elsevier Science B.V All rights reserved.
引用
收藏
页码:90 / 99
页数:10
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