Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

被引：207

作者：

Allen, Bryan G. ^{[1
]}

Bhatia, Sudershan K. ^{[1
]}

Anderson, Carryn M. ^{[1
]}

Eichenberger-Gilmore, Julie M. ^{[1
]}

Sibenaller, Zita A. ^{[1
]}

Mapuskar, Kranti A. ^{[1
]}

Schoenfeld, Joshua D. ^{[1
]}

Buatti, John M. ^{[1
]}

Spitz, Douglas R. ^{[1
]}

Fath, Melissa A. ^{[1
]}

机构：

[1] Univ Iowa, Dept Radiat Oncol, Holden Comprehens Canc Ctr, Free Rad & Radiat Biol Program, Iowa City, IA 52242 USA

来源：

REDOX BIOLOGY | 2014年 / 2卷

关键词：

Ketogenic diet; Oxidative stress; Cancer therapy; MITOCHONDRIAL-DNA MUTATIONS; INDUCED OXIDATIVE STRESS; LOW-FAT DIET; LOW-CARBOHYDRATE; PROSTATE-CANCER; KETONE-BODIES; SUPEROXIDE-DISMUTASE; H2O2; MEDIATE; TUMOR-CELLS; WEIGHT-LOSS;

D O I：

10.1016/j.redox.2014.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cancer cells, relative to normal cells, demonstrate significant alterations in metabolism that are proposed to result in increased steady-state levels of mitochonclrial-derived reactive oxygen species (ROS) such as O-2(center dot-) and H2O2. It has also been proposed that cancer cells increase glucose and hydroperoxide metabolism to compensate for increased levels of ROS. Given this theoretical construct, it is reasonable to propose that forcing cancer cells to use mitochondrial oxidative metabolism by feeding ketogenic diets that are high in fats and low in glucose and other carbohydrates, would selectively cause metabolic oxidative stress in cancer versus normal cells. Increased metabolic oxidative stress in cancer cells would in turn be predicted to selectively sensitize cancer cells to conventional radiation and chemotherapies. This review summarizes the evidence supporting the hypothesis that ketogenic diets may be safely used as an adjuvant therapy to conventional radiation and chemotherapies and discusses the proposed mechanisms by which ketogenic diets may enhance cancer cell therapeutic responses. (C) 2014 The Authors. Published by Elsevier B.V.

引用

页码：963 / 970

页数：8

共 79 条

[1]

Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: Role of oxidative stress [J].