Accelerated memory decline in Alzheimer's disease with apolipoprotein ε4 allele

被引：44

作者：

Hirono, N ^{[1
]}

Hashimoto, M

Yasuda, M

Kazui, H

Mori, E

机构：

[1] Ehime Univ, Sch Med, Fac Hlth Sci, Dept Clin Neurosci, Shigenobu, Ehime 7910295, Japan

[2] Ehime Univ, Sch Med, Fac Hlth Sci, Dept Basic Neurosci,Hyogo Inst Aging Brain & Cogn, Shigenobu, Ehime 7910295, Japan

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2003年 / 15卷 / 03期

关键词：

D O I：

10.1176/appi.neuropsych.15.3.354

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To investigate a possible effect of the apolipoprotein (APOE) epsilon4 allele on memory decline in Alzheimer's disease (AD), we examined 64 AD patients with the APOE epsilon3/3, epsilon3/4, or epsilon4/4 allele using the Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and its subtests at the initial examination and at the 1-year follow-up visit. One-year changes in the scores of the Word Recall subtest, Word Recognition subtest, and total ADAS-Cog were significantly correlated with the number of APOE epsilon4 alleles after controlling for the effects of age, sex, education, test interval, and baseline scores. Findings revealed that APOE epsilon4 allele is related to an accelerated memory decline in AD.

引用

页码：354 / 358

页数：5

共 39 条

[1] APOE genotype:: No influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease [J].

Aerssens, J ;

Raeymaekers, P ;

Lilienfeld, S ;

Geerts, H ;

Konings, F ;

Parys, W .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2001, 12 (02) :69-77

[2] APOLIPOPROTEIN EPSILON-4 ALLELE AND DISEASE PROGRESSION IN PATIENTS WITH LATE-ONSET ALZHEIMERS-DISEASE [J].

BASUN, H ;

GRUT, M ;

WINBLAD, B ;

LANNFELT, L .

NEUROSCIENCE LETTERS, 1995, 183 (1-2) :32-34

[3] Clinicopathologic studies in cognitively healthy aging and Alzheimer disease - Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype [J].

Berg, L ;

McKeel, DW ;

Miller, JP ;

Storandt, M ;

Rubin, EH ;

Morris, JC ;

Baty, J ;

Coats, M ;

Norton, J ;

Goate, AM ;

Price, JL ;

Gearing, M ;

Mirra, SS ;

Saunders, AM .

ARCHIVES OF NEUROLOGY, 1998, 55 (03) :326-335

[4]

Bigler ED, 2000, AM J NEURORADIOL, V21, P1857

[5] ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative [J].

Blacker, D ;

Haines, JL ;

Rodes, L ;

Terwedow, H ;

Go, RCP ;

Harrell, LE ;

Perry, RT ;

Bassett, SS ;

Chase, G ;

Meyers, D ;

Albert, MS ;

Tanzi, R .

NEUROLOGY, 1997, 48 (01) :139-147

[6] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[7] Accelerated decline in apolipoprotein E-ε4 homozygotes with Alzheimer's disease [J].

Craft, S ;

Teri, L ;

Edland, SD ;

Kukull, WA ;

Schellenberg, G ;

McCormick, WC ;

Bowen, JD ;

Larson, EB .

NEUROLOGY, 1998, 51 (01) :149-153

[8]

DalForno G, 1996, ARCH NEUROL-CHICAGO, V53, P345

[9] APOE-ε4 is associated with memory decline in cognitively impaired elderly [J].

Dik, MG ;

Jonker, C ;

Bouter, LM ;

Geerlings, MI ;

van Kamp, GJ ;

Deeg, DJH .

NEUROLOGY, 2000, 54 (07) :1492-1497

[10] Metrifonate treatment of AD -: Influence of APOE genotype [J].

Farlow, MR ;

Cyrus, PA ;

Nadel, A ;

Lahiri, DK ;

Brashear, A ;

Gulanski, B .

NEUROLOGY, 1999, 53 (09) :2010-2016

← 1 2 3 4 →