Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene

被引：38

作者：

Kitano, T ^{[1
]}

Sumiyama, K

Shiroishi, T

Saitou, N

机构：

[1] Natl Inst Genet, Lab Evolutionary Genet, Mishima, Shizuoka 4118540, Japan

[2] Natl Inst Genet, Mammalian Genet Lab, Mishima, Shizuoka 4118540, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 249卷 / 01期

关键词：

evolutionary rate; phylogenetic tree; window analysis; positive selection;

D O I：

10.1006/bbrc.1998.9074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have sequenced the complete coding region of the Rh blood group gene for mouse and rat and that of Rh-related 50 kD glycoprotein (Rh50) for mouse, rat, and crab-eating macaque. Phylogenetic analyses of Rh and Rh50 amino acid sequences indicate that the Rh50 gene has been evolving about two times more slowly than the Rh blood group gene in both primates and rodents. This conservative nature of the Rh50 gene suggests its relative importance to the Rh blood group gene. The time of gene duplication that produced the Rh and Rh50 genes was estimated to be about 240-310 million years ago. We also conducted window analyses of synonymous and nonsynonymous nucleotide substitutions for those two genes. Some peaks where nonsynonymous substitutions are higher than synonymous ones were located on outer membrane regions. This suggests the existence of positive Darwinian selection on Rh and Rh50 genes through host-parasite interactions. (C) 1998 Academic Press.

引用

页码：78 / 85

页数：8

共 31 条

[1]

ARCE MA, 1993, BLOOD, V82, P651

[2] CDNA CLONING OF A 30-KDA ERYTHROCYTE-MEMBRANE PROTEIN ASSOCIATED WITH RH (RHESUS)-BLOOD-GROUP-ANTIGEN EXPRESSION [J].

AVENT, ND ;

RIDGWELL, K ;

TANNER, MJA ;

ANSTEE, DJ .

BIOCHEMICAL JOURNAL, 1990, 271 (03) :821-825

[3]

AVENT ND, 1992, J BIOL CHEM, V267, P15134

[4] LOCALIZATION OF THE HUMAN RH BLOOD-GROUP GENE STRUCTURE TO CHROMOSOME REGION 1P34.3-1P36.1 BY INSITU HYBRIDIZATION [J].

CHERIFZAHAR, B ;

MATTEI, MG ;

LEVANKIM, C ;

BAILLY, P ;

CARTRON, JP ;

COLIN, Y .

HUMAN GENETICS, 1991, 86 (04) :398-400

[5] MOLECULAR-CLONING AND PROTEIN-STRUCTURE OF A HUMAN BLOOD-GROUP RH POLYPEPTIDE [J].

CHERIFZAHAR, B ;

BLOY, C ;

LEVANKIM, C ;

BLANCHARD, D ;

BAILLY, P ;

HERMAND, P ;

SALMON, C ;

CARTRON, JP ;

COLIN, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6243-6247

[6] Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency [J].

CherifZahar, B ;

Raynal, V ;

Gane, P ;

Mattei, MG ;

Bailly, P ;

Gibbs, B ;

Colin, Y ;

Cartron, JP .

NATURE GENETICS, 1996, 12 (02) :168-173

[7]

Eder AF., 1997, MOL BIOL EVOLUTION B, P268

[8] Large-scale search for genes on which positive selection may operate [J].

Endo, T ;

Ikeo, K ;

Gojobori, T .

MOLECULAR BIOLOGY AND EVOLUTION, 1996, 13 (05) :685-690

[9]

EYERS SAC, 1994, J BIOL CHEM, V269, P6417

[10]

INA Y, 1994, COMPUT APPL BIOSCI, V10, P11

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