Micrometastatic p53-positive cells in the lymph nodes of early stage epithelial ovarian cancer: Prognostic significance

被引：14

作者：

Suzuki, M ^{[1
]}

Ohwada, M ^{[1
]}

Saga, Y ^{[1
]}

Kohno, T ^{[1
]}

Takei, Y ^{[1
]}

Sato, I ^{[1
]}

机构：

[1] Jichi Med Sch, Dept Obstet & Gynecol, Kawachi, Tochigi 3290498, Japan

来源：

ONCOLOGY | 2001年 / 60卷 / 02期

关键词：

ovarian cancer; epithelial; lymph node; regional; p53; immunohistochemistry; micrometastasis;

D O I：

10.1159/000055315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We used immunohistochemical staining of p53 protein to detect micrometastasis in regional lymph nodes that were judged tumor-free by conventional histopathological methods in 58 patients with stage I or II (pT1 or 2, N0) epithelial ovarian cancer. Overexpression of p53 protein in the primary lesions of ovarian cancer was observed in 31 patients (53%), and p53 protein-positive cells were detected in the regional lymph nodes (micrometastasis-positive) in 19 of 31 patients with p53 protein overexpression (61%). In patients with micrometastasis, the prognosis was significantly poorer than that in those without micrometastasis (p < 0.05). Detection of micrometastasis of the regional lymph nodes of ovarian cancer by immunohistochemical staining of p53 protein may be useful in predicting the prognosis of patients with stage I or II epithelial ovarian cancer. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：170 / 175

页数：6

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