Microbial production and applications of chiral hydroxyalkanoates

被引：114

作者：

Chen, GQ ^{[1
]}

Wu, Q

机构：

[1] Tsing Hua Univ, Dept Biol Sci & Biotechnol, MOE Lab Prot Sci, Beijing 100084, Peoples R China

[2] Shantou Univ, Multidisciplinary Res Ctr, Shantou 515063, Guangdong, Peoples R China

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2005年 / 67卷 / 05期

关键词：

D O I：

10.1007/s00253-005-1917-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polyhydroxyalkanoates (PHA) are a family of polyesters consisting of over 150 chiral hydroxyalkanoic acids (HA). This paper reviews the physiological functions of (R)-3-hydroxybutyric acid (3HB) and (R)-4-hydroxybutyric acid and summarizes the technologies developed to produce various HA [3HB, (R)-3-hydroxyoctanoic acid, (R)-3-hydroxydecanoic acid, etc.] and the applications of chiral HA. Their outlooks and perspectives are discussed.

引用

页码：592 / 599

页数：8

共 52 条

[1]

Addolorato G, 1996, ALCOHOL ALCOHOLISM, V31, P341

[2]

ANGELO DP, 1996, GENET ENG NEWS, V6, P15

[3] RAPID GAS-CHROMATOGRAPHIC METHOD FOR DETERMINATION OF POLY-BETA-HYDROXYBUTYRIC ACID IN MICROBIAL BIOMASS [J].

BRAUNEGG, G ;

SONNLEITNER, B ;

LAFFERTY, RM .

EUROPEAN JOURNAL OF APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1978, 6 (01) :29-37

[4]

Chen GQ, 2000, CHINESE J POLYM SCI, V18, P389

[5] A SYNTHETIC APPROACH TO (+)-THIENAMYCIN FROM METHYL (R)-3-HYDROXYBUTANOATE - A NEW ENTRY TO (3R,4R)-3-[(R)-1-HYDROXYETHYL]-4-ACETOXY-2-AZETIDINONE [J].

CHIBA, T ;

NAKAI, T .

CHEMISTRY LETTERS, 1985, (05) :651-654

[6]

Cleere Henry, 1995, Chirality and the Biological Activity of Drugs

[7]

Crosby J., 1992, CHIRALITY IND, P1

[8] Ketone bodies and brain glutamate and GABA metabolism [J].

Daikhin, Y ;

Yudkoff, M .

DEVELOPMENTAL NEUROSCIENCE, 1998, 20 (4-5) :358-364

[9] Ion channels formed by biomimetic Oligo-(R)-3-hydroxybutyrates and inorganic polyphosphates in planar lipid bilayers [J].

Das, S ;

Kurcok, P ;

Jedlinski, Z ;

Reusch, RN .

MACROMOLECULES, 1999, 32 (26) :8781-8785

[10] Proof for a nonproteinaceous calcium-selective channel in Escherichia coli by total synthesis from (R)-3-hydroxybutanoic acid and inorganic polyphosphate [J].

Das, S ;

Lengweiler, UD ;

Seebach, D ;

Reusch, RN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9075-9079

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