Signal transduction by vascular endothelial growth factor receptors

被引：640

作者：

Koch, Sina ^{[1
]}

Tugues, Sonia ^{[1
]}

Li, Xiujuan ^{[1
]}

Gualandi, Laura ^{[1
]}

Claesson-Welsh, Lena ^{[1
]}

机构：

[1] Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden

来源：

BIOCHEMICAL JOURNAL | 2011年 / 437卷

关键词：

angiogenesis; internalization; neuropilin; signal transduction; vascular endothelial growth factor (VEGF); vascular endothelial growth factor receptor (VEGFR); PROTEIN-KINASE-C; NITRIC-OXIDE SYNTHASE; VEGF-INDUCED ANGIOGENESIS; FOCAL ADHESION KINASE; MAJOR BINDING-SITE; TYROSINE KINASE; HEPARIN-BINDING; LIGAND-BINDING; EXTRACELLULAR-MATRIX; ADAPTER PROTEIN;

D O I：

10.1042/BJ20110301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling.

引用

页码：169 / 183

页数：15

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