Motor coordination deficits in mice lacking RGS9

被引：42

作者：

Blundell, Jacqueline ^{[1
]}

Hoang, Chau V. ^{[2
]}

Potts, Bryan ^{[2
]}

Gold, Stephen J. ^{[2
]}

Powell, Craig M. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

来源：

BRAIN RESEARCH | 2008年 / 1190卷

关键词：

RGS9; motor coordination; working memory; delayed-match-to-place water maze; dopamine; striatum;

D O I：

10.1016/j.brainres.2007.11.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：78 / 85

页数：8

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