Optogenetics in Neural Systems

被引：1372

作者：

Yizhar, Ofer ^{[1
]}

Fenno, Lief E. ^{[1
]}

Davidson, Thomas J. ^{[1
]}

Mogri, Murtaza ^{[1
]}

Deisseroth, Karl ^{[1
,2
,3
,4
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[3] Stanford Univ, CNC Program, Stanford, CA 94305 USA

[4] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

NEURON | 2011年 / 71卷 / 01期

关键词：

ADENOASSOCIATED VIRUS VECTORS; CENTRAL SEROTONERGIC NEURONS; RESTORES VISUAL RESPONSES; WIDESPREAD GENE DELIVERY; IN-VIVO CONTROL; OPTICAL CONTROL; REMOTE-CONTROL; CORTICAL-NEURONS; ION CHANNELS; MILLISECOND-TIMESCALE;

D O I：

10.1016/j.neuron.2011.06.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both observational and perturbational technologies are essential for advancing the understanding of brain function and dysfunction. But while observational techniques have greatly advanced in the last century, techniques for perturbation that are matched to the speed and heterogeneity of neural systems have lagged behind. The technology of optogenetics represents a step toward addressing this disparity. Reliable and targetable single-component tools (which encompass both light sensation and effector function within a single protein) have enabled versatile new classes of investigation in the study of neural systems. Here we provide a primer on the application of optogenetics in neuroscience, focusing on the single-component tools and highlighting important problems, challenges, and technical considerations.

引用

页码：9 / 34

页数：26

共 204 条

[1] Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, Antoine R.
Zhang, Feng
Aravanis, Alexander M.
Deisseroth, Karl
De Lecea, Luis
[J]. NATURE, 2007, 450 (7168) : 420 - U9
[2] Lateral competition for cortical space by layer-specific horizontal circuits
Adesnik, Hillel
Scanziani, Massimo
[J]. NATURE, 2010, 464 (7292) : 1155 - U71
[3] High-speed Imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, Raag D.
Meltzer, Leslie A.
Roy, Madhuri
Gong, Yuqing
Chen, Han
Deisseroth, Karl
[J]. SCIENCE, 2007, 317 (5839) : 819 - 823
[4] Temporally precise in vivo control of intracellular signalling
Airan, Raag D.
Thompson, Kimberly R.
Fenno, Lief E.
Bernstein, Hannah
Deisseroth, Karl
[J]. NATURE, 2009, 458 (7241) : 1025 - 1029
[5] Light-Induced Rescue of Breathing after Spinal Cord Injury
Alilain, Warren J.
Li, Xiang
Horn, Kevin P.
Dhingra, Rishi
Dick, Thomas E.
Herlitze, Stefan
Silver, Jerry
[J]. JOURNAL OF NEUROSCIENCE, 2008, 28 (46) : 11862 - 11870
[6] Two-photon single-cell optogenetic control of neuronal activity by sculpted light
Andrasfalvy, Bertalan K.
Zemelman, Boris V.
Tang, Jianyong
Vaziri, Alipasha
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (26) : 11981 - 11986
[7] AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Yexica
Atasoy, Deniz
Sternson, Scott M.
[J]. NATURE NEUROSCIENCE, 2011, 14 (03) : 351 - 355
[8] An optical neural interface:: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology
Aravanis, Alexander M.
Wang, Li-Ping
Zhang, Feng
Meltzer, Leslie A.
Mogri, Murtaza Z.
Schneider, M. Bret
Deisseroth, Karl
[J]. JOURNAL OF NEURAL ENGINEERING, 2007, 4 (03) : S143 - S156
[9] In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
Arenkiel, Benjamin R.
Peca, Joao
Davison, Ian G.
Feliciano, Catia
Deisseroth, Karl
Augustine, George J.
Ehlers, Michael D.
Feng, Guoping
[J]. NEURON, 2007, 54 (02) : 205 - 218
[10] Optogenetic Control of Cardiac Function
Arrenberg, Aristides B.
Stainier, Didier Y. R.
Baier, Herwig
Huisken, Jan
[J]. SCIENCE, 2010, 330 (6006) : 971 - 974

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