Turn me on: regulating HIF transcriptional activity

被引：182

作者：

Lisy, K. ^{[1
,2
]}

Peet, D. J. ^{[1
,2
]}

机构：

[1] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia

[2] Univ Adelaide, ARC Special Res Ctr Mol Genet Dev, Adelaide, SA 5005, Australia

来源：

CELL DEATH AND DIFFERENTIATION | 2008年 / 15卷 / 04期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

HIF; hypoxia; transcription; FIH-1; oxygen;

D O I：

10.1038/sj.cdd.4402315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hypoxia-inducible factors (HIFs) are critical for cellular adaptation to limiting oxygen and regulate a wide array of genes when cued by cellular oxygen-sensing mechanisms. HIF is able to direct transcription from either of two transactivation domains, each of which is regulated by distinct mechanisms. The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1 alpha (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen sensation and HIF-mediated transcription. Additionally, there are phosphorylation and nitrosylation events reported to modulate HIF transcriptional activity, as well as numerous transcriptional coactivators and other interacting proteins that together provide cell and tissue specificity of HIF target gene regulation.

引用

收藏

页码：642 / +

页数：9

相关论文

共 68 条

[1] An essential role for p300/CBP in the cellular response to hypoxia [J].

Arany, Z ;

Huang, LE ;

Eckner, R ;

Bhattacharya, S ;

Jiang, C ;

Goldberg, MA ;

Bunn, HF ;

Livingston, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :12969-12973

[2] Sumoylation increases HIF-1 stability and its transcriptional activity [J].

Bae, SH ;

Jeong, JW ;

Park, JA ;

Kim, SH ;

Bae, MK ;

Choi, SJ ;

Kim, KW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 324 (01) :394-400

[3] Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia [J].

Beischlag, TV ;

Taylor, RT ;

Rose, DW ;

Yoon, D ;

Chen, YM ;

Lee, WH ;

Rosenfeld, MG ;

Hankinson, O .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (52) :54620-54628

[4] Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species [J].

Bell, Eric L. ;

Chandel, Navdeep S. .

OXYGEN SENSING AND HYPOXIA-INDUCED RESPONSES, 2007, 43 :17-27

[5] SUMOylation of hypoxia-inducible factor-lα reduces its transcriptional activity [J].

Berta, Melanie A. ;

Mazure, Nathalie ;

Hattab, Maurice ;

Pouyssegur, Jacques ;

Brahimi-Horn, M. Christiane .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 360 (03) :646-652

[6] Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment [J].

Bracken, Cameron P. ;

Fedele, Anthony O. ;

Linke, Sarah ;

Balrak, Wiltiana ;

Lisy, Karolina ;

Whitelaw, Murray L. ;

Peet, Daniel J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (32) :22575-22585

[7] Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator [J].

Bracken, CP ;

Whitelaw, ML ;

Peet, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (14) :14240-14251

[8] The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses [J].

Bracken, CP ;

Whitelaw, ML ;

Peet, DJ .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (07) :1376-1393

[9] RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia [J].

Carbia-Nagashima, Alberto ;

Gerez, Juan ;

Perez-Castro, Carolina ;

Paez-Pereda, Marcelo ;

Silberstein, Susana ;

Stalla, Guenter K. ;

Holsboer, Florian ;

Arzt, Eduardo .

CELL, 2007, 131 (02) :309-323

[10] Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α [J].

Carrero, P ;

Okamoto, K ;

Coumailleau, P ;

O'Brien, S ;

Tanaka, H ;

Poellinger, L .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (01) :402-415

← 1 2 3 4 5 6 7 →