Earliest mineral and matrix changes in force-induced musculoskeletal disease as revealed by Raman microspectroscopic imaging

被引：38

作者：

Tarnowski, CP

Ignelzi, MA

Wang, W

Taboas, JM

Goldstein, SA

Morris, MD

机构：

[1] Univ Michigan, Sch Dent, Dept Orthodont & Pediat Dent, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Orthopaed Res Lab, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 01期

关键词：

craniosynostosis; suture; skull; bone; mechanical force;

D O I：

10.1359/JBMR.0301201

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Craniosynostosis, premature fusion of the skull bones at the sutures, is the second most common human birth defect in the skull. Raman microspectroscopy was used to examine the composition, relative amounts, and locations of the mineral and matrix produced in mouse skulls undergoing force-induced craniosynostosis. Raman imaging revealed decreased relative mineral content in skulls undergoing craniosynostosis compared with unloaded specimens.

引用

页码：64 / 71

页数：8

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