Modeling and prediction of electrophoretic mobilities in capillary electrophoresis: Reparation of alkylpyridines

The relative electrophoretic mobilities of a series of closely related alkylpyridines in capillary electrophoresis have Been predicted by proposing that they experience a preferred orientation under the influence of the applied electrical held, This means that analytes with the same van der Weals volumes can exhibit different effective hydrodynamic radii to motion through the buffer solution. Additional terms for these differences in apparent volume and for the forces acting to orient the analytes can be calculated from the molecular structures and influence the dominant effect of the total volume. The model could correctly predict the relative mobility of structural, positional, and geometric isomers of alkylated and unsaturated pyridines.