Heparan sulfate proteoglycans in glomerular inflammation

被引:100
作者
Rops, ALWMM
van der Vlag, J
Lensen, JFM
Wijnhoven, TJM
van den Heuvel, LPWJ
van Kuppevelt, TH
Berden, JHM
机构
[1] Univ Med Ctr Nijmegen, Div Nephrol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Med Ctr Nijmegen, Div Pediat, NL-6500 HB Nijmegen, Netherlands
[3] Nijmegen Ctr Mol Life Sci, Nephrol Res Lab, Nijmegen, Netherlands
[4] Nijmegen Ctr Mol Life Sci, Lab Matrix Biochem, Nijmegen, Netherlands
关键词
heparan sulfate proteoglycans; renal; glomerulus; inflammation;
D O I
10.1111/j.1523-1755.2004.00451.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Heparan sulfate proteoglycans (HSPGs) are glycoproteins consisting of a core protein to which linear heparan sulfate side chains are covalently attached. These heparan sulfate side chains can be modified at different positions by several enzymes, which include N-deacetylases, N- and O-sulfotransferases, and an epimerase. These heparan sulfate modifications give rise to an enormous structural diversity, which corresponds to the variety of biologic functions mediated by heparan sulfate, including its role in inflammation. The HSPGs in the glomerular basement membrane (GBM), perlecan, agrin, and collagen XVIII, play an important role in the charge-selective permeability of the glomerular filter. In addition to these HSPGs, various cell types express HSPGs at their cell surface, which include syndecans, glypicans, CD44, and betaglycan. During inflammation, HSPGs, especially heparan sulfate, in the extracellular matrix (ECM) and at the surface of endothelial cells bind chemokines, which establishes a local concentration gradient recruiting leukocytes. Endothelial and leukocyte cell surface HSPGs also play a role in their direct adhesive interactions via other cell surface adhesion molecules, such as selectins and beta(2) integrin. Activated leukocytes and endothelial cells exert heparanase activity, resulting in degradation of heparan sulfate moieties in the ECM, which facilitates leukocyte passage into tissues and the release of heparan sulfate-bound factors. In various renal inflammatory diseases the expression of agrin and GBM-associated heparan sulfate is decreased, while the expression of CD44 is increased. Heparan sulfate or heparin preparations affect inflammatory cell behavior and have promising therapeutic, anti-inflammatory properties by preventing leukocyte adhesion/influx and tissue damage.
引用
收藏
页码:768 / 785
页数:18
相关论文
共 184 条
[1]   LEUKOCYTE-ENDOTHELIAL INTERACTIONS AND REGULATION OF LEUKOCYTE MIGRATION [J].
ADAMS, DH ;
SHAW, S .
LANCET, 1994, 343 (8901) :831-836
[2]   Examination of the function of RANTES, MIP-1α, and MIP-1β following interaction with heparin-like glycosaminoglycans [J].
Ali, S ;
Palmer, ACV ;
Banerjee, B ;
Fritchley, SJ ;
Kirby, JA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :11721-11727
[3]   Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis [J].
Ali, S ;
Palmer, ACV ;
Fritchley, SJ ;
Maley, Y ;
Kirby, JA .
BIOCHEMICAL JOURNAL, 2001, 358 :737-745
[4]   Stromal cell-derived factor-1α associates with heparan sulfates through the first β-strand of the chemokine [J].
Amara, A ;
Lorthioir, O ;
Valenzuela, A ;
Magerus, A ;
Thelen, M ;
Montes, M ;
Virelizier, JL ;
Delepierre, M ;
Baleux, F ;
Lortat-Jacob, H ;
Arenzana-Seisdedos, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :23916-23925
[5]   MEMBRANE-ANCHORED AND SOLUBLE FORMS OF BETAGLYCAN, A POLYMORPHIC PROTEOGLYCAN THAT BINDS TRANSFORMING GROWTH FACTOR-BETA [J].
ANDRES, JL ;
STANLEY, K ;
CHEIFETZ, S ;
MASSAGUE, J .
JOURNAL OF CELL BIOLOGY, 1989, 109 (06) :3137-3145
[6]   Chemokines and leukocyte traffic [J].
Baggiolini, M .
NATURE, 1998, 392 (6676) :565-568
[7]   Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans [J].
Bame, KJ .
GLYCOBIOLOGY, 2001, 11 (06) :91R-98R
[8]   COMPARATIVE-ANALYSIS OF THE ABILITY OF LEUKOCYTES, ENDOTHELIAL-CELLS AND PLATELETS TO DEGRADE THE SUBENDOTHELIAL BASEMENT-MEMBRANE - EVIDENCE FOR CYTOKINE DEPENDENCE AND DETECTION OF A NOVEL SULFATASE [J].
BARTLETT, MR ;
UNDERWOOD, PA ;
PARISH, CR .
IMMUNOLOGY AND CELL BIOLOGY, 1995, 73 (02) :113-124
[9]   BASEMENT-MEMBRANE HEPARAN-SULFATE PROTEOGLYCAN BINDS TO LAMININ BY ITS HEPARAN-SULFATE CHAINS AND TO NIDOGEN BY SITES IN THE PROTEIN CORE [J].
BATTAGLIA, C ;
MAYER, U ;
AUMAILLEY, M ;
TIMPL, R .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 208 (02) :359-366
[10]   A new class of membrane-bound chemokine with a CX(3)C motif [J].
Bazan, JF ;
Bacon, KB ;
Hardiman, G ;
Wang, W ;
Soo, K ;
Rossi, D ;
Greaves, DR ;
Zlotnik, A ;
Schall, TJ .
NATURE, 1997, 385 (6617) :640-644