Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction

被引：82

作者：

Colombo, Pierre-Emmanuel ^{[2
]}

Milanezi, Fernanda ^{[2
]}

Weigelt, Britta ^{[1
]}

Reis-Filho, Jorge S. ^{[2
]}

机构：

[1] Canc Res UK London Res Inst, Signal Transduct Lab, London WC2A 3LY, England

[2] Inst Canc Res, Breakthrough Breast Canc Res Ctr, Mol Pathol Team, London SW3 6JB, England

来源：

BREAST CANCER RESEARCH | 2011年 / 13卷 / 03期

关键词：

MOLECULAR SUBTYPES; PREOPERATIVE CHEMOTHERAPY; NEOADJUVANT PACLITAXEL; GRADE INDEX; CYCLOPHOSPHAMIDE CHEMOTHERAPY; RETROSPECTIVE ANALYSIS; INTRINSIC SUBTYPES; GENOMIC SIGNATURES; RECURRENCE SCORE; CLINICAL-TRIALS;

D O I：

10.1186/bcr2890

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer comprises a collection of diseases with distinctive clinical, histopathological, and molecular features. Importantly, tumors with similar histological features may display disparate clinical behaviors. Gene expression profiling using microarray technologies has improved our understanding of breast cancer biology and has led to the development of a breast cancer molecular taxonomy and of multigene 'signatures' to predict outcome and response to systemic therapies. The use of these prognostic and predictive signatures in routine clinical decision-making remains controversial. Here, we review the clinical relevance of microarray-based profiling of breast cancer and discuss its impact on patient management.

引用

页数：15

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