Synthetic strategy of nonreducing iterative polyketide Synthases and the origin of the classical "Starter-Unit effect"

被引:34
作者
Crawford, Jason M. [1 ]
Vagstad, Anna L. [1 ]
Whitworth, Karen R. [1 ]
Ehrlich, Kenneth C. [2 ]
Townsend, Craig A. [1 ]
机构
[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA
[2] USDA, So Reg Res Ctr, New Orleans, LA 70124 USA
关键词
biosynthesis; fatty acids; fungal metabolites pigments; polyketides;
D O I
10.1002/cbic.200700702
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1019 / 1023
页数:5
相关论文
共 29 条
  • [1] Secondary metabolite biosynthesis: The first century
    Bentley, R
    [J]. CRITICAL REVIEWS IN BIOTECHNOLOGY, 1999, 19 (01) : 1 - 40
  • [2] Aspergillus has distinct fatty acid synthases for primary and secondary metabolism
    Brown, DW
    Adams, TH
    Keller, NP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14873 - 14877
  • [3] The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae
    Choquer, M
    Dekkers, KL
    Chen, HQ
    Cao, LH
    Ueng, PP
    Daub, ME
    Chung, KR
    [J]. MOLECULAR PLANT-MICROBE INTERACTIONS, 2005, 18 (05) : 468 - 476
  • [4] Starter unit specificity directs genome mining of polyketide synthase pathways in fungi
    Crawford, Jason M.
    Vagstad, Anna L.
    Ehrlich, Kenneth C.
    Townsend, Craig A.
    [J]. BIOORGANIC CHEMISTRY, 2008, 36 (1-3) : 16 - 22
  • [5] Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
    Crawford, Jason M.
    Dancy, Blair C. R.
    Hill, Eric A.
    Udwary, Daniel W.
    Townsend, Craig A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) : 16728 - 16733
  • [6] Heterologous expression and product identification of Colletotrichum lagenarium polyketide synthase encoded by the PKS1 gene involved in melanin biosynthesis
    Fujii, I
    Mori, Y
    Watanabe, A
    Kubo, Y
    Tsuji, G
    Ebizuka, Y
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1999, 63 (08) : 1445 - 1452
  • [7] Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans
    Fujii, I
    Watanabe, A
    Sankawa, U
    Ebizuka, Y
    [J]. CHEMISTRY & BIOLOGY, 2001, 8 (02): : 189 - 197
  • [8] Hydrolytic polyketide shortening by Ayg1p, a novel enzyme involved in fungal melanin biosynthesis
    Fujii, I
    Yasuoka, Y
    Tsai, HF
    Chang, YC
    Kwon-Chung, KJ
    Ebizuka, Y
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) : 44613 - 44620
  • [9] Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1
    Fujii, I
    Mori, Y
    Watanabe, A
    Kubo, Y
    Tsuji, G
    Ebizuka, Y
    [J]. BIOCHEMISTRY, 2000, 39 (30) : 8853 - 8858
  • [10] Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis
    Hitchman, TS
    Schmidt, EW
    Trail, F
    Rarick, MD
    Linz, JE
    Townsend, CA
    [J]. BIOORGANIC CHEMISTRY, 2001, 29 (05) : 293 - 307