Preparation, characterization, swelling and in vitro drug release behaviour of poly [N-acryloylglycine-chitosan interpolymeric pH and thermally-responsive hydrogels

被引：82

作者：

El-Sherbiny, IM

Lins, RJ

Abdel-Bary, EM

Harding, DRK ^{[1
]}

机构：

[1] Massey Univ, Chem Dept, Inst Fundamental Sci, Palmerston North 5301, New Zealand

[2] Univ Mansoura, Fac Sci, Dept Chem, Polymer Lab, ET-35516 Mansoura, Egypt

来源：

EUROPEAN POLYMER JOURNAL | 2005年 / 41卷 / 11期

关键词：

IPN; hydrogel; biodegradable; chitosan; in vitro release;

D O I：

10.1016/j.eurpolymj.2005.05.035

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel biodegradable pH- and thermal-responsive interpenetrating polymer network (IPN) hydrogels were prepared for controlled drug delivery Studies. The IPN hydrogels were obtained in mild aqueous acid media by irradiation of solutions of N-acryloylglycine (NAGly) mixed with chitosan, in the presence of glutaraldehyde as a crosslinking agent and using 2,2-dimethoxy-2-phenyl acetophenone as photoinitiator. These hydrogels were subjected to equilibrium swelling studies at different temperatures (25 degrees C, 37 degrees C and 45 degrees C in buffer solutions of pH 2.1 and 7.4 (similar to that of gastric and intestinal fluids respectively). 5-Fluorouracil (5-FU) was entrapped in the hydrogels, and drug release Studies carried Out at 37 degrees C in buffer solutions at pH 2.1 and 7.4. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2584 / 2591

页数：8

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