A comparative study of the calcium system in memory T cells and naive T cells

被引：17

作者：

Sigova, A

Dedkova, E

Zinchenko, V ^{[1
]}

Litvinov, I

机构：

[1] Russian Acad Sci, Inst Cell Biophys, Lab Intracellular Signaling, Pushchino 142292, Moscow Region, Russia

[2] Russian Acad Sci, Shemjakin Ovchinnikov Inst Bioorgan Chem, Lab Immunochem, Moscow 117871, Russia

来源：

FEBS LETTERS | 1999年 / 447卷 / 01期

关键词：

immunological memory; T lymphocyte; Ca2+ transport; ionophore;

D O I：

10.1016/S0014-5793(99)00260-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The comparative analysis of responses of memory and naive T lymphocytes to Ca2+-mobilizing agents, namely cbn A, thimerosal, thapsigargin and ionomycin, nas carried out. The effect of these agents on both types of T cells differed qualitatively and quantitatively. The lack of intracellular Ca2+ stores in memory T cells was shown. Ca2+-mobilizing agents did not induce influx of Ca2+ in memory T cells from outside and this was the reason for their stability to Ca2+ ionophores, It was also shown that memory T cells were resistant to the 'Ca2+ paradox'. (C) 1999 Federation of European Biochemical Societies.

引用

页码：34 / 38

页数：5

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