Bilirubin and tryptophan adsorption in albumin-containing solutions. I. Equilibrium isotherms on activated carbon

被引：35

作者：

Annesini, Maria Cristina ^{[1
]}

Di Carlo, Chiara ^{[1
]}

Piemonte, Vincenzo ^{[1
]}

Turchetti, Luca ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Chem Engn Mat & Environm, I-00184 Rome, Italy

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2008年 / 40卷 / 02期

关键词：

adsorption; amino acid; artificial liver; bilirubin; modelling;

D O I：

10.1016/j.bej.2007.12.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Albumin-bound toxins are involved in the aetiology of many liver failure associated pathologies and specific processes aimed to their removal have been developed. In general, adsorption plays an important role in all of these processes. In this paper, two albumin-bound toxins (bilirubin and tryptophan) were considered and their adsorption equilibrium on activated carbon in albumin-containing solutions was investigated. The experimental results clearly show that the higher the albumin concentration in the liquid phase, the lower the toxin adsorbed amount. This effect was quantitatively analysed by means of a mathematical model that accounts for chemical and non-chemical interactions between albumin and toxin adsorption. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：205 / 210

页数：6

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