Expression of atrC -: encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans -: is sensitive to cycloheximide

被引：23

作者：

Angermayr, K

Parson, W

Stöffler, G

Haas, H

机构：

[1] Univ Innsbruck, Sch Med, Dept Microbiol, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Sch Med, Inst Forens Med, A-6020 Innsbruck, Austria

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1999年 / 1453卷 / 02期

关键词：

ABC transporter; cycloheximide; (Aspergillus nidulans);

D O I：

10.1016/S0925-4439(98)00107-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new member of the ABC superfamily of transmembrane proteins in Aspergillus nidulans has been cloned and characterized. The topology of conserved motifs subgroups AtrC in the P-glycoprotein cluster of ABC permeases, the members of this subfamily, are known to participate in multidrug resistance (MDR) in diverse organisms. Alignment results display significant amino acid similarity to AfuMDR1 and AflMDR1 from Aspergillus fumigatus and flavus, respectively. Northern analysis reveals that atrC mRNA levels are 10-fold increased in response to cycloheximide. Evidence for the existence of eight additional hitherto unpublished ABC transporter proteins in A. nidulans is provided. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：304 / 310

页数：7

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