Genotoxic evaluation of the antimicrobial drug, trimethoprim, in cultured human lymphocytes

被引：21

作者：

Abou-Eisha, A ^{[1
]}

Creus, A ^{[1
]}

Marcos, R ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Genet & Microbiol, Unitat Genet, Grp Mutagenesi, E-08193 Bellaterra, Cerdanyola, Spain

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1999年 / 440卷 / 02期

关键词：

trimethoprim; diaminopyrimidine; human lymphocyte; sister chromatid exchange (SCE); micronucleus;

D O I：

10.1016/S1383-5718(99)00022-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The antimicrobial drug, trimethoprim, was evaluated for genotoxicity in human peripheral blood lymphocyte cultures set-up from two healthy donors. Sister-chromatid exchanges (SCE) and micronuclei (MN) were scored as genetic endpoints. The treatment was done using different trimethoprim concentrations ranging from I to 100 mu g/ml. From our results, we can conclude that this drug is able to induce both cytotoxic and moderate genotoxic effects, as revealed by the increases seen in SCE and MN frequencies in cultures from the two donors and, at least, at one of the concentrations tested. (C) 1999 Elsevier Science B.V. Ail rights reserved.

引用

页码：157 / 162

页数：6

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