RD Lawrence Lecture 2008 - Targeting GLP-1 release as a potential strategy for the therapy of Type 2 diabetes

被引：20

作者：

Gribble, F. M. ^{[1
,2
]}

机构：

[1] Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England

[2] Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 0XY, England

来源：

DIABETIC MEDICINE | 2008年 / 25卷 / 08期

基金：

英国惠康基金;

关键词：

GLP-1; GIP; incretin;

D O I：

10.1111/j.1464-5491.2008.02514.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are gastrointestinal hormones that play an important role in stimulating postprandial insulin release from pancreatic beta-cells. Agents that either mimic GLP-1 or prevent its degradation are now available for the treatment of Type 2 diabetes, and strategies to enhance endogenous GLP-1 release are under assessment. As intestinal peptides have a range of actions, including appetite regulation and coordination of fat metabolism, harnessing the enteric endocrine system is a promising new field for drug development.

引用

收藏

页码：889 / 894

页数：6

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